TY - JOUR
T1 - Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus
AU - Ishii, Kazunari
AU - Kawaguchi, Tetsuro
AU - Shimada, Kenichi
AU - Ohkawa, Shingo
AU - Miyamoto, Naokazu
AU - Kanda, Tomonori
AU - Uemura, Takafumi
AU - Yoshikawa, Toshiki
AU - Mori, Etsuro
PY - 2008/4
Y1 - 2008/4
N2 - Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.
AB - Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.
KW - Alzheimer's disease
KW - Idiopathic normal pressure hydrocephalus
KW - Magnetic resonance imaging
KW - Voxel-based morphometry
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U2 - 10.1159/000119521
DO - 10.1159/000119521
M3 - Article
C2 - 18319598
AN - SCOPUS:42449136625
SN - 1420-8008
VL - 25
SP - 329
EP - 335
JO - Dementia
JF - Dementia
IS - 4
ER -
